Longevity and Stress Resistance Conferred by Targeted Overexpression of Mitochondrial Drosophila Peroxiredoxin MtDPX (thioredoxin Peroxidase Dpx-5037) in Drosophila Melanogaster

Longevity and Stress Resistance Conferred by Targeted Overexpression of Mitochondrial Drosophila Peroxiredoxin MtDPX (thioredoxin Peroxidase Dpx-5037) in Drosophila Melanogaster

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The Oxidative Stress Hypothesis of Aging postulates that the imbalance between oxidative stress and antioxidant defenses results in the accumulation of oxidative stress/damage with age and thus serves as a limiting factor on longevity. Glutathione reductase and glutathione peroxidase represent an important enzymatic component of the antioxidant system in most organisms (including mammals). In Drosophila melanogaster and several other insects, these enzymes are absent. There is however a second group of enzymes, thioredoxin reductase and thioredoxin peroxidases, which may in part replace the glutathione-dependent system in insects. These enzymes then may play an important role in insect aging.From 3rd to 2nd chromosome G0 (mass mating ) a™€a™€ yw;p[ w+]/III X a™‚a™‚ yw; Sp/ Cyo; delta2-3Sb/TM6Ubx G1 (mass mating ) ... Indianapolis, IN, USA) by capillary downward transfer (Molecular Cloning, A Laboratory Manual, 3rd Edition, vol.


Title:Longevity and Stress Resistance Conferred by Targeted Overexpression of Mitochondrial Drosophila Peroxiredoxin MtDPX (thioredoxin Peroxidase Dpx-5037) in Drosophila Melanogaster
Author: Genying Niu
Publisher:ProQuest - 2006
ISBN-13:

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